Overview
Pharmaceutical and biotech production has the strictest demands on online density / concentration measurement: hygienic wetted design, GMP compliance, CIP/SIP cleanability, full traceability. From fermenters through crystallizers to dosing tanks and purified-water systems, density is a key validation parameter.
Typical challenges
- Sanitary wetted parts: 316L mirror polish, Tri-Clamp connections
- CIP/SIP cleaning at 130°C for extended cycles
- Small-batch, multi-product operations require quick re-calibration
- 21 CFR Part 11 and GMP data integrity