INDUSTRY 04

Pharma / Biotech

04 / PHARMA

GMP-grade sanitary wetted parts for fermentation & crystallization.

8 applicable products 3 application cases
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Overview

Pharmaceutical and biotech production has the strictest demands on online density / concentration measurement: hygienic wetted design, GMP compliance, CIP/SIP cleanability, full traceability. From fermenters through crystallizers to dosing tanks and purified-water systems, density is a key validation parameter.

Typical challenges

  • Sanitary wetted parts: 316L mirror polish, Tri-Clamp connections
  • CIP/SIP cleaning at 130°C for extended cycles
  • Small-batch, multi-product operations require quick re-calibration
  • 21 CFR Part 11 and GMP data integrity
RECOMMENDED PRODUCTS

Products that fit this industry

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PS7010

Acoustic attenuation density meter

The PS7010 series ultrasonic acoustic-attenuation slurry density meter employs a dual-probe through-beam measurement configuration, addressing the challenges of retrofitting aging pipelines and monitoring in hazardous‑area environments. The instrument leverages the energy attenuation of ultrasonic waves as they propagate through the slurry to accurately determine the slurry’s density and concentration, making it ideal for industries such as chemical processing, sugar refining, and mining.
PS7020

Sound Velocity Concentration Meter

The PS7020 series ultrasonic sound-velocity concentration/density meter measures the time of flight of ultrasonic waves in a liquid, and—combined with temperature compensation and an extensive library of calibration curves—converts this data in real time to yield the medium’s concentration and density, addressing the low accuracy and susceptibility to interference inherent in conventional measurement methods. Leveraging the fundamental physical principles of the sound-velocity method, this instrument is entirely immune to the effects of liquid color, transparency, electrical conductivity, vibration, noise, and flow velocity, thereby guaranteeing high precision and exceptional stability.
PS7400

Online tuning fork density meter

The PS7400 series online tuning fork density meter monitors liquid density in real time by leveraging piezoelectric excitation and changes in the tuning fork’s resonant frequency, requiring no maintenance while delivering highly accurate, repeatable measurements. Its built-in PT1000 temperature compensation eliminates drift due to temperature variations, making it suitable for diverse industrial applications such as pipelines and storage tanks, and widely used in the petrochemical, chemical, and pharmaceutical industries.
PS7200

Coriolis density meter

The PS7210 density meter employs the Coriolis force principle and achieves high‑precision, long‑term stability with no sensor drift through pure‑physical frequency measurement. It is suitable for continuous online monitoring of a wide range of liquids, including those in the petrochemical, brewing, and chemical industries—covering acids and alkalis—and supports installation in bypass lines or buffer tanks.
PS7110

Refractive concentration meter

The PS7110 series online refractive concentration meter uses high-resolution spectral acquisition and temperature-compensation algorithms to accurately convert the refractive index of a liquid into concentration, making it suitable for a wide range of industrial processes. Based on the principle of the critical angle of total internal reflection, the instrument features no moving parts and requires no reagents or consumables; it is unaffected by bubbles, color, or turbidity, ensuring long-term stability and maintenance-free operation.
PS7100

Spectroscopic concentration meter

The PS7100 series spectral concentration/density meter employs multi-channel full-spectrum technology to deliver real-time, reagent-free, and undiluted high-precision concentration measurements. Based on the Lambert–Beer law, this instrument provides broad coverage across the ultraviolet, visible, and near-infrared spectra, making it suitable for industries such as chemicals, pharmaceuticals, and food & beverage, and particularly well‑suited for concentration monitoring in complex multiphase systems.
PS7600

Microwave concentration/density meter

The PS7600 series online microwave density meter accurately captures the phase shift and amplitude attenuation of microwaves in the medium, thereby providing real-time measurements of slurry concentration, density, and moisture content. Employing a non‑nuclear, zero‑radiation microwave phase‑shift method coupled with Pt‑100 temperature compensation, it is ideally suited for challenging applications such as flue‑gas desulfurization in thermal power plants and coal‑washing slurries.
PS7300

Pipeline Differential Pressure Density Meter

Online differential pressure density meter uses a special density sensor to measure the density of various liquids or liquid mixtures online, directly reads the density value and outputs a 4-20mA DC signal with HART communication protocol. It is widely
APPLICATION CASES

Cases in this industry

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Spectroscopic concentration meter · PS7100

Online Monitoring Solution for Methanol–Water Binary System

At the outlet pipeline of the circulation pump in the methanol distillation unit, the customer faced high risks of personnel exposure during manual sampling, a 2–3 hour delay in laboratory analysis, and an inability to adjust the water content in real time. The PS7100 explosion-proof spectral concentration meter was installed in a bypass flow cell, enabling simultaneous online monitoring of methanol and water content via near-infrared characteristic wavelengths, delivering sub-second response, non-contact measurement, and real-time DCS feedback.

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Spectroscopic concentration meter · PS7100

HF + H₂SO₄ + H₃PO₄ + DI Water Simultaneous Monitoring of Multi-Component Tank Solution Concentrations

Semiconductor 12-inch wafer foundries face challenges in BHF and SPM etching tanks: the concentrations of the four components—HF, H₂SO₄, H₃PO₄, and DI water—are prone to drift, making real-time monitoring difficult; manual sampling is both hazardous and time‑lagged; and reliance on empirical judgment for tank‑change timing leads to chemical waste or yield degradation. The PS7100 spectral‑based concentration meter, equipped with a PFA‑lined flow cell and sapphire optical windows, delivers online, synchronous concentration measurements for all four components, enabling sub‑second feedback and precise management of bath life.

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Spectroscopic concentration meter · PS7100

Multicomponent online analysis of substrate + byproduct + biomass + target product

During biopharmaceutical fermentation, customers face challenges such as infrequent offline sampling, high contamination risks, and the need for multiple sets of equipment to analyze multiple components, resulting in prolonged fermentation cycles and fluctuating product yields. The PS7100 spectral concentration/density meter enables online monitoring across the UV–Vis–NIR full spectrum, allowing a single instrument to simultaneously quantify glucose, ethanol, biomass, the target product, and byproducts. Compatible with CIP/SIP sterilization, it delivers sterile, continuous, real-time multivariate analysis.

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Industry FAQ

Can Pisonics meters be used in pharma GMP / FDA validation?

Yes. Pisonics offers GMP-compliant versions for the pharmaceutical industry:

  1. Wetted materials—316L electropolished, PTFE, and sapphire;
  2. Process connections—sanitary Tri-Clamp clamps (DIN 32676 / ISO 2852);
  3. Surface finish—Ra ≤ 0.4 μm mirror polish;
  4. Validation documentation—IQ/OQ validation documents, material traceability certificates (EN 10204 3.1), and surface roughness reports are provided upon shipment;
  5. CIP/SIP compatibility—withstanding steam sterilization at 134°C.

Typical applications: sugar/alcohol concentration in fermenter external circulation lines (PS7110 refractive index), concentration during injection solution preparation (PS7210 Coriolis), API crystallization (PS7300 differential pressure), and PAT process analysis (PS7100 spectroscopy). It has also passed a 21 CFR Part 11 audit.

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